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KMID : 0604520150410010001
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Journal of the Society of Cosmetic Scientists of Korea
2015 Volume.41 No. 1 p.1 ~ p.7
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The Protective Effects of Cornus walteri Wanger Leaves against UV Induced Cellular Damage in Human Fibroblast
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Park Hyun-Chul
Jung Taek-Kyu
Yoon Kyung-Sup
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Abstract
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Cornus walteri Wanger has been used in folk medicine in Korea. Ultraviolet (UV) irradiation has been known as a major cause of photo damage in skin. In the present study, research on how to cure damaged cells by UVB was conducted using an extract of Cornus walteri Wanger leaves (CWE), which was treated with an enzyme. CWE was applied to human dermal fibroblasts (HDFs) affected by UVB. UVB-irradiated HS68 cells showed increased caspase-3 activity, phosphorylation of p53, γH2AX, cyclobutane pyrimidine dimers (CPDs) formation, and DNA fragmentation compared with non-irradiated cells. However, all these effects were inhibited by treatment with CWE for 12 h after UVB irradiation. Furthermore, CWE has proved not to cause primary skin irritation through the human patch test. Collectively, these results suggest that CWE could be a new potential candidate as photoprotective agent against UVB-induced cellular damage in HDFs.
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KEYWORD
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Cornus walteri Wanger, UVB-irradiation, human dermal fibroblast (HDF), apoptosis, photoprotection
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